Consider the following graph:
At the point where the curve is the lowest, the slope of the line tangent to the curve has a slope of zero. Calculus is used to find the point where the function is a minimum, i.e., where the slope of the tangent line is zero.
Deriving the Least Squares Regression Coefficients:
The Regression Equation
Computational Simplification
From Calculus...
Derivation of the Constant
More Calculus...
Deriving the Regression Coefficient
In Deviation Score Form